Gabapentin-induced coma in a patient with renal failure

We describe a 60-year-old woman who became comatose after a single dose of gabapentin for right-sided sciatalgia. The patient was improved by hemodialysis. Gabapentin toxicity should be considered when mental status changes develop in patients with renal failure after even a single dose.     

CIRCUMFERENTIAL CRACK PROBLEM FOR AN FGM CYLINDER UNDER THERMAL STRESSES

The main objective of this study is to determine the stress intensity factors associated with a circumferential crack in a thin-walled cylinder subjected to quasi-static thermal loading. The cylinder is assumed to be a functionally graded material. In order to make the problem analytically tractable, the thin-walled cylinder is modeled as a layer on an elastic foundation whose thermal and mechanical properties are exponential functions of the thickness coordinate. Hence a plane strain crack problem is obtained. First temperature and thermal stress distributions for a crack-free layer are determined. Then using these solutions, the crack problem is reduced to a local perturbation problem where the only nonzero loads are the crack surface tractions. Both internal and edge cracks are considered. Stress intensity factors are computed as functions of crack geometry, material properties, and time.     

Hygrothermal Fracture Analysis of Orthotropic Materials Using J k -Integral

A new computational method based on the J _k -integral is put forward for the purpose of conducting fracture analysis of orthotropic materials subjected to hygrothermal stresses. By utilizing the constitutive relations of plane orthotropic hygrothermoelasticity, an alternative expression for the J _k -integral is derived to replace the general limit definition. A numerical procedure is developed and integrated into a finite element analysis software to implement the proposed form of the J _k -integral. Temperature and specific moisture concentration fields, which are required in fracture calculations, are also computed through finite element analysis. Numerical results are generated by considering an embedded crack in a polymer matrix fibrous composite laminate, that is subjected to steady-state hygrothermal loading. Comparisons of the mixed-mode stress intensity factors computed by the J _k -integral based method to those evaluated via the displacement correlation technique demonstrate that, the proposed form of the J _k -integral is domain independent and leads to numerical results of high accuracy. Presented parametric analyses illustrate the influences of the fiber volume fraction and the crack location on the modes I and II stress intensity factors, the energy release rate, and the T-stress.     

Au-Sn SLID Bonding: A Reliable HT Interconnect and Die Attach Technology

Au-Sn solid–liquid interdiffusion (SLID) bonding is an established reliable high temperature (HT) die attach and interconnect technology. This article presents the life cycle of an optimized HT Au-Sn SLID bond, from fabrication, via thermal treatment, to mechanical rupture. The layered structure of a strong and uniform virgin bond was identified by X-ray diffraction to be Au/ζ (Au_0.85Sn_0.15)/Au. During HT exposure, it was transformed to Au/β (Au_1.8Sn_0.2)/Au. After HT exposure, the die shear strength was reduced by 50 pct, from 14 Pa to 70 MPa, which is still remarkably high. Fractographic studies revealed a change in fracture mode; it was changed from a combination of adhesive Au/Ni and cohesive SiC fracture to a cohesive β-phase fracture. Design rules for high quality Au-Sn SLID bonds are given.     

Low phase-noise VCO utilizing modified symmetric load and partial positive feedback for FDSM

The voltage-controlled oscillator (VCO) in frequency-based $\Updelta\Upsigma$ modulator (FDSM) systems behaves as a voltage-to-phase integrator converting an analog input voltage to phase information. Tuning range and phase noise are the most important factors of the basic design of a VCO in FDSM systems. In this paper a novel low phase-noise and wide tuning-range differential VCO based on a differential ring oscillator with modified symmetric load and a partial positive feedback in the differential delay cell is presented. The VCO is combined with a new bias circuit and implemented using 90 nm CMOS process technology. By using modified NMOS symmetric loads and a PMOS tail for delay cells, the VCO phase noise can be reduced with more than 13 dB compared to that of the conventional approach, achieving ?125 dBc/Hz at 500 kHz offset from the center frequency of 450 MHz. The wide tuning-range by using two added transistors (parallel with the active loads) increases the operating frequency range by about 22%, while the partial positive feedback provides the necessary bias condition for the circuit to oscillate. The designed VCO operating at a low power supply voltage of 0.6V can achieve low power consumption of 670???W at oscillation frequency of 800 MHz and good linearity reducing harmonic distortion in the $\Updelta\Upsigma$ modulator.     

Verbal memory in drug-naive, newly diagnosed Parkinson's disease. The retrieval deficit hypothesis revisited.

Objective: The retrieval deficit hypothesis on memory impairment in patients with Parkinson's disease (PD) implies a selective impairment in recall of learned material with normal encoding, retention, and recognition. This hypothesis has been challenged by new data. We have therefore investigated verbal memory and learning in a large sample of newly diagnosed, drug na?ve, non-demented patients with PD. Method: From a sample of patients with PD from the Norwegian ParkWest study, 133 PD patients and 133 controls matched on sex, age, and education were included. The California Verbal Learning Test-2 (CVLT-2) was used to assess verbal memory. Results: Patients performed significantly worse than controls on free and cued recall as well as on recognition memory. Patients used the semantic clustering learning strategy significantly less extensively than the controls and the learning slope of the PD patients was significantly less steep. There was no difference in retention when controlling for encoding. Patients did not perform better on the recognition measure or on cued recall (d-prime), as compared to free recall. Executive functions explained a substantial part of the memory deficits. Conclusions: This study suggests that memory impairment in drug na?ve early PD to a large degree is a deficit of learning/ encoding and not of retention or retrieval. An implication is that the retrieval deficit hypothesis should be moderated in its general form. Executive deficits and less extensive use of the efficient semantic clustering learning strategy had a strong impact on learning and memory. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Micro X-ray diffraction mapping of a fluorene copolymer fibre

Using raster-scanning wide-angle X-ray scattering, we investigate oriented fibres of the low bandgap conjugated polymer, poly[2,7-(9,9-dioctylfluorene)-alt-5,5-(4′,7′-di-2-thienyl-2′,1′,3′-benzothiadiazole)] (F8TBT), that was developed in particular for polymer solar cells. For the first time, structural data are provided for F8TBT. Our results demonstrate that the nano-scale structure of this polymer is closely related to the externally observable features of the fibre, and thus emphasise the importance of having full control over the local molecular conformation. Liquid-crystalline phases are observed at elevated temperatures, and the molecular alignment in the drawn fibres yields scattering patterns that are dominated by broad peaks of equatorial diffuse scattering. The significant degree of preferred orientation facilitates the analysis, leading to estimates of (average) nearest-neighbour packing distances and coherence length of this macromolecule. In particular, we observe a pronounced broad signal assigned to packing of the conjugated backbone with an approximate spacing of 4.00–4.39 Å that is coherent over 5-6 polymer segments.     

Molten‐Salt‐Assisted Self‐Assembly (MASA)‐Synthesis of Mesoporous Metal Titanate‐Titania,Metal Sulfide‐Titania,and Metal Selenide‐Titania Thin Films

New synthetic strategies are needed for the assembly of porous metal titanates and metal chalcogenite‐titania thin films for various energy applications. Here, a new synthetic approach is introduced in which two solvents and two surfactants are used. Both surfactants are necessary to accommodate the desired amount of salt species in the hydrophilic domains of the mesophase. The process is called a molten‐salt‐assisted self‐assembly (MASA) because the salt species are in the molten phase and act as a solvent to assemble the ingredients into a mesostructure and they react with titania to form mesoporous metal titanates during the annealing step. The mesoporous metal titanate (meso‐Zn₂TiO₄ and meso‐CdTiO₃) thin films are reacted under H₂S or H₂Se gas at room temperature to yield high quality transparent mesoporous metal chalcogenides. The H₂Se reaction produces rutile and brookite titania phases together with nanocrystalline metal selenides and H₂S reaction of meso‐CdTiO₃ yields nanocrystalline anatase and CdS in the spatially confined pore walls. Two different metal salts (zinc nitrate hexahydrate and cadmium nitrate tetrahydrate) are tested to demonstrate the generality of the new assembly process. The meso‐TiO₂‐CdSe film shows photoactivity under sunlight.     

Pattern Noise in the Frequency ΔΣ Modulator

In this paper, we show that the first-order frequency delta–sigma modulator is equivalent to a traditional delta–sigma modulator with respect to pattern noise. We further propose two techniques for reducing the effect of pattern noise. The first technique is based on time-domain dithering which is implemented by adding white phase noise to the FM signal. The second technique is based on locating the narrow dynamic range that may be in this kind of modulators, in a pattern noise valley. This technique can utilize pattern noise to make the modulator provide significantly higher digital resolution than the white quantization noise model predicts. Finally, the theory is verified by measurements.     

Homogenization of some variational problems connected to the theory of lubrication

An important problem in the theory of lubrication is to model and analyze the effects of surface roughness on the hydrodynamic performance. An efficient method to do this is homogenization. In this paper we prove a general homogenization result which allows us to consider unstationary variational problems, related to Reynolds type equations, where the lubricant may be Newtonian or non-Newtonian. Recently, the idea of finding upper and lower bounds on the effective behavior, obtained by homogenization, was applied for the first time in tribology. The homogenization result in this work may therefore also serve as a rigorous starting point for developing these successful results to unstationary problems.